One of the greatest things about blogging is the immediate feedback a blogger gets from readers. Unfortunately, too much of a good thing can be challenging and problematic. Fortunately, WordPress has some great comment moderation tools.
This screencast demonstrates how to manage comments in WordPress. It also provides a in-depth overview of the WordPress discussion settings. Combined with the Akismet SPAM filter, discussion settings have a huge impact on the quality of comments that are published on your website.
For a more detailed discussion of Akismet, see the video on fighting SPAM.